PANCE vs. PANRE vs. PANRE-LA: What's the Difference? The PANCE, PANRE, and PANRE-LA are certification exams from National Commission on Certification of Physician Assistants for Physician Assistants. The PANCE is a one-time 300-question exam for new graduates to earn certification. The PANRE is a 240-question recertification exam taken every 10 years. The PANRE-LA offers a flexible option with 25 quarterly online questions, letting experienced PAs maintain certification through ongoing assessment instead of one large exam. Learn more at https://cme4life.com/pance-panre-panre-la/